Bio-Data

Particulars of organization, functions and duties

Name : Dr. Anil Kumar Singh

Designation : Principal Scientist & Associate Professor

Education : Ph.D (Life sciences) Bose Institute, Kolkata, Post Doctoral Research Fellow, NECKER Institute, Paris, France.

Contact Details: +91-(0)376-2372951 +91-8876954752

Email id : anil@neist.res.in, 1010anil@gmail.com

Research Interest

• Mechanistic understanding of bacterial drug resistance in human and animals
• Development of therapeutics and diagnostics against resistant bacteria
• Microbial Genetics and gene regulation
• Environmental microbiology
• Clinical microbiology and bacterial genomics

Research Opportunity/ Student Corner

• Motivated students (with their own fellowship or looking for fellowship) are encouraged to contact with their Biodata and with one page of research interests.
• M. Sc. students can apply for their six months dissertation works in our lab.

Patent

• Singh AK, Sen T, Gogoi P, Neog K (2021) Synergistic composition of novel quinazolinone compounds with rifampicin to potentiate efficacy against Mycobacterium tuberculosis (Patent application no. 202111054718, National filling date: 26th November 2021).
• Singh AK, Devi MV, Maurya AW, Borra S, Hati Boruah JL, Borkotoky L. (2023) Synergistic composition of 2-Amino benzofuran derivative with rifampicin to potentiate efficacy against Mycobacterium abscessus(Patent application no. 202311045256, National filling date: 5th July 2023).

Projects Affiliated

• CSIR
• CSIR-Open Source Drug Discovery, CSIR-OSDD
• DST-SERB
• DBT
• Oil India Limited

List of Publications

PUBLICATIONS:

• Bhattacharjee A and Singh AK* (2024) Delineating the acquired Genetic diversity and Multidrug resistance in Alcaligenes from Poultry farms and nearby soil. Journal of Microbiology(In Press)(IF: 3.7)
• Devi MV and Singh AK*(2023)Delineation of transcriptional regulators involve in biofilm formation cycle of Mycobacterium abscessus. Gene, 882, 147644. https://doi.org/10.1016/j.gene.2023.147644.(IF: 3.5)
• Bhattacharjee A, Sarma S, Sen T, Devi MV, Deka B, Singh AK* (2023) Genome mining to identify valuable secondary metabolites and their regulation in Actinobacteria from different niches. Archives of Microbiology, 205(4):127. doi: 10.1007/s00203-023-03482-3. PMID: 36944761.(IF: 2.8).
• Sarma S, Bhattacharjee A, Devi MV, Panyang PP, Singh AA* (2023) Long-term adaptation of ParA, RelE/ParE partition system, replication protein and phage proteins encoding low-cost plasmids of Escherichia species isolated from diarrheic children of North East of India. Journal of Applied Microbiology. https://doi.org/10.1093/jambio/lxac065. (IF: 4.059)
• Wahengbam R, Bharali P, Manna P, Phukan T, Singh MG, Gogoi G, Tapadar YB, Singh AK, et al. Seroepidemiological and genomic investigation of SARS-CoV-2 spread in North East region of India (2022) Indian J Med Microbiol., S0255-0857(22)00237-7. doi: 10.1016/j.ijmmb.2022.10.011. (IF: 1.35)
• Bhattacharjee A, Sarma S, Sen T, Singh AK* (2022) Alterations in molecular responses of Mycobacterium tuberculosis against anti tuberculosis drugs. Molecular Biology Report., 49(5):3987-4002. (IF: 2.74)
• Deka B, Suri M, Sarma S, Devi MV, Bora A, T Sen, Dihingia A, Pahari P, Singh AK* (2022) Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. Bioorganic and Medicinal Chemistry, 54 (2022) 116580. https://doi.org/10.1016/j.bmc.2021.116580. (IF: 3.46)
• arma S, Deka B, Panyang PP, Singh AK* (2021) Identification of Arg32Ser, His92Tyr and Leu147Phe novel mutations in chromosomally mediated β-lactamase SHV and in silico characterization to understand their substrate activity imparting resistance. Journal of Biomolecular Structure and Dynamics Sep 25;1-15. (IF: 4.152)
• Kashyap D, Baral B, Jakhmola S, Singh AK, Jha HC (2021) Helicobacter pylori and Epstein-Barr Virus Coinfection Stimulates Aggressiveness in Gastric Cancer through the Regulation of Gankyrin. mSphere 6(5): e0075121. (IF: 4.389)
• Choudhury, A., Lahkar, J., Saikia, B.K., Singh A.K., et al. (2021) Strategies to address coal mine-created environmental issues and their feasibility study on northeastern coalfields of Assam, India: a review. Environ Dev Sustain 23, 9667–9709. (IF: 4.080)
• Das D, Mawlong GT, Sarki YN, Singh AK, Chikkaputtaiah C, Deka Boruah HP. (2020) Transcriptome analysis of crude oil degrading Pseudomonas aeruginosa strains for identification of potential genes involved in crude oil degradation. Gene 755: 144909. (IF: 3.913)
• Goswami K, Sehgal A, Lahkar J, Neog D, Hussain TA, Singh AK, Deka Boruah HP. (2020) Remediation of crude oil contaminated pit water using Pseudomonas aeruginosa strains. Advances in Biotechnology and Microbiology, 15(5), DOI: 10.19080/AIBM.2020.15.555922.
• Sen T, Neog K, Sarma S, Manna P, Deka Boruah HP, Gogoi P, Singh AK* (2018) Efflux pump inhibition by 11H-pyrido[2,1-b]quinazolin-11-one analogues in mycobacteria. Bioorganic and Medicinal Chemistry 26(17):4942-4951. (IF: 3.46)
• Baruah R, Mishra SK, Kalita DJ, Silla Y, Chauhan PS, Singh AK, Deka Boruah HP. (2017) Assessment of bacterial diversity associated with crude oil contaminated soil samples from Assam. International Journal of Environmental Science and Technology, p-1-18. (doi:10.1007/s13762-017-1294-2). (IF: 3.519)
• Talukdar M, Das D, Borah C, Bora TC, Deka Boruah HP, Singh AK*. (2016) Complete genome sequencing and comparative analyses of broad-spectrum antimicrobial-producing Micromonospora sp. HK10, Gene, 594: 97-107. (IF: 3.913)
• Talukdar M, Das D, Borah C, Deka Boruah HP, Bora TC and Singh AK*, (2016) Draft genome sequence of Micromonospora sp. HK10 strain, isolated from Kaziranga national park, India. Genome Announcement, 4: e00559-15.
• Baruah R, Singh AK, Saikia B, Deka Boruah HP (2016) Native hydrocarbonoclastic bacteria and their hydrocarbon mineralization processes. Int. Biodeterioration & Biodegradation. 112: 18-30. (IF: 4.907)
• Das D, Baruah R, Singh AK*, Deka Boruah HP, Borah M, Sarma Roy A, Kalita J and TC Bora. (2015) Complete genome sequence analysis of Pseudomonas aeruginosa N002 reveals its genetic adaptation for crude oil degradation. Genomics, 105: 182-90. (IF: 4.31)
• Anand A, Verma P, Singh AK, et al. (2015) Polyketide quinolones are intermediate electron carrier during mycobacterial respiration in oxygen-deficient niches. Molecular Cell. 60(4):637-50. (IF: 19.33)
• Das D, Borah M, Das R, Singh AK, Deka Boruah HP. (2015) Molecular docking of phytochemical as FtsZ cell division protein inhibitor in Mycobacterium tuberculosis. International J. Pharmaceutical Sciences and Research, 6: 463-472.
• Sarma Roy A, Barua R, Borah M, Singh AK*, Deka Boruah, HP, Saikia N, Deka M, Dutta N, Bora TC. (2014) Soil microcosm study of crude oil degradation using native bacterial strains isolated from selected hydrocarbon contaminated sites of Assam, India. International Biodeterioration & Biodegradation, 94: 79-89. (IF: 4.907)
• Saikia P, Kaishap PP, Goswami J, Singh AK, Deka Boruah HP, Gogoi S, Boruah RC. (2014). Synthesis of steroidal/nonsteroidal vicinal heterocyclic alcohols, N-(1-cycloalkenyl) heterocycles and their antibacterial studies. Steroids Mar 28; 84C:36-45. (IF : 2.76)
• Sarma Roy A, Baruah R, Gogoi D, Bora M, Singh AK* and Deka Boruah HP. (2013) Full genome sequence of Pseudomonas aeruginosa strain N002, isolated from crude oil contaminated soil from Geleky, Assam, India. Genome announcement, 1 (1): e00104-12.
• Sarma Roy A, Yenn R, Singh AK, Deka Boruah HP, Saikia N, Deka M. (2013) Crude oil bioremediation of tea plantation soil using two Pseudomonas aeruginosa strains AS03 and NA108. A. Journal of Biotechnology, 12: 2600-2610.
• Vats A, Singh A#, Mukhjerjee R, Chopra T, Madhusudan R, Mohanty D, Chatterji D, Reyrat JM and Gokhale RS. (2012) Retrobiosynthesis approach delineates the biosynthetic pathway and the structure of the acyl chain of mycobacterial glycopeptidolipids. Journal of Biological Chemistry; 287(36): 30677-87 (#As first equal authorship). (IF: 5.486)
• Cortes M, Singh AK, Reyrat JM, Gaillard JL, Nassif X, and Herrmann JL. (2011) Conditional Gene Expression in Mycobacterium abscessus. PLoS ONE; 6 (12): e29306. Epub 2011 Dec 15. (IF : 3.752)
• Cortes M, Nessar R and Singh AK*, Laboratory maintenance of Mycobacterium abscessus. Current protocols in microbiology, Chapter 10:Unit 10D.1, (2010) Aug.
• Medjahed H and Singh AK*. Genetic manipulations of Mycobacterium abscessus. Current protocols in microbiology, Chapter 10:Unit 10D.2, (2010) Aug.
• Singh AK and Reyrat JM. Laboratory maintenance of Mycobacterium smegmatis. Current protocols in microbiology Chapter 10: Unit10C.1, (2009) Aug.
• Kocincova D, Singh AK, Euphrasie D, Beretti JL, Ren H, Liu J, Daffé M, Etienne G and Reyrat J-M. (2008) Spontaneous transposition of IS1096 or ISMsm3 leads to glycopeptidolipid over production and affects surface properties in Mycobacterium smegmatis. Tuberculosis, 88: 390-398. (IF: 2.973)
• Pazhani GP, Niyogi SK, Singh AK, Sen B, Taneja N, Kundu M, Yamasaki S, and Ramamurthy T. (2008) Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India. Journal of Medical Microbiol., 57(Pt 7): 856-863. (IF: 3.197)
• Saha B, Singh AK, Ghosh A and Bal M. (2008) Identification and Characterization of a Vancomycin resistance Staphylococcus aureus isolated from Kolkata, South Asia. Journal of Medical Microbiol., 57: 72-79. (IF: 3.197)
• Sureka K, Dey S, Datta P, Singh AK, Dasgupta A, Rodrigue S, Basu J and Kundu M. (2007) Polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria. Molecular Microbiology, 65: 261-276. (IF: 3.501)
• Singh AK, Halder R, Mandal D and Kundu M. (2006) Analysis of the topology of norM of Vibrio cholerae and identification of amino acids residues involved in norfloxacin resistance. Antimicrob. Agents Chemother. 50: 3717-3723. (IF: 5.938)
• Datta P, Dasgupta A, Singh AK, Mukherjee P, Kundu M and Basu J. (2006). Interaction between FtsW and penicillin-binding protein 3 (PBP3) directs PBP3 to mid-cell, controls cell septation and mediates the formation of a trimeric complex involving FtsZ, FtsW and PBP3 in mycobacteria. Molecular Microbiology, 62: 1655-1673. (IF: 3.501)
BOOK CHAPTER:
• Lal M, Parasar NR, Singh AK, Akhtar MS (2018) Potentiality of Anticancer Plant-Derived Compounds of North-East India. In: Akhtar M., Swamy M. (eds) Anticancer plants: Properties and Application. Springer, Singapore.

*As corresponding Author
#As first equal authorship

Awards and Fellowships
• Marie-Curie Fellowship (MC-IIF) (2009-2011)
• AXA Postdoctoral fellowship, Paris, France (2008-2009)
  (AXA Research fund selects 30 young researchers from all over world)
• Indo-French (CEFIPRA-IFCPAR) Postdoctoral fellowship (2007-2008)
• CSIR-UGC-National Eligibility Test (NET) (July, 2001)