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सीएसआईआर - उत्तर पूर्व विज्ञान एवं प्रौद्योगिकी संस्थान
CSIR-North East Institute of Science and Technology

Applied Organic Chemistry Group

Highlight of the Group:
Applied Organic Chemistry Group (AOCG), which is under Chemical Science & Technology Division (CSTD) of CSIR-NEIST, Jorhat is dedicated for frontline research in applied & application oriented basic organic chemistry. The group is actively engaged, for last several years in the area of bioactive molecules with main emphasis being laid on the development of process route for drugs/drug intermediates and synthesis of new molecular entities (NMEs) on lead molecules as well as for lead generation. The main focus on the synthesis of new molecular entities is based on known drug molecules and bioactive molecules identified from natural sources. A major thrust of the AOCG is directed in the development of process/heterogeneous recyclable catalyst for industrially important speciality chemicals. The group is also involved in the synthesis of stable metal nanoparticles on nanoporous biopolymers/cellulose templates and their application in organic synthesis.

Head of the Division

Dr Archanamoni Das

Senior Principal Scientist

Education : M Phil, Ph D (Organic chemistry)

ID. No.: 1051

Email:archanamoni@neist.res.in, amd_das2001@yahoo.co.in

contact No : +91 0376 2370121 extn. 2364 Fax:0376-2370011

Group Leader

Dr. Sanjib Gogoi

Senior Principal Scientist

Education :M.Sc, Ph D

ID. No.: 1181

Email: sanjibgogoi@neist.res.in

contact No : ext. 2369 Fax:0376-2370011

Area's of Interest : Synthetic Organic Chemistry

Scientists

Dr. Pranjal Gogoi

Principal Scientist

Education :Ph D (Organic chemistry)

ID. No.: 1179

Email: pranjalgogoi@neist.res.in

contact No :ext. 2369 Fax:0376-23700111

Area's of Interest : Medicinal Chemistry

Dr. Pallab Pahari

Principal Scientist

Education :Ph D (Organic Chemistry)

ID. No.: 1185

Email:pallab@neist.res.in

contact No : Fax:0376-2370011

Area’s of Interest : Organic synthesis, enzymatic synthesis, Bio synthesis.

Dr. Ram Awatar Maurya

Principal Scientist

Education :Ph D

ID. No.: 1252

Email: ram.cdri@gmail.com, rammaurya@neist.res.in

contact No : Fax: 0376-2370011

Area’s of Interest : Medicinal Chemistry, Synthetic Organic Chemistry, Photochemistry, Flow Microreactor Chemistry

Dr. Arup Roy

Sr. Scientist

Education :Ph D

ID. No.: 1268

Email: arup.csir@gmail.com, aroy@neist.res.in

contact No : Fax:0376-2370011

Area's of Interest : Foldamer, Molecular self-assembly, Medicinal Chemistry, Synthetic Organic Chemistry. Personal Website

Dr P Yuvaraj

Principal Scientist

Education :Ph D

ID. No.: 1253

Email: pyuvraj@neist.res.in, yuvaraj.orgchem@gmail.com

contact No : +91 0385-2414481

Area's of Interest : Synthetic Organic Chemistry, Medicinal Chemistry, Asymmetric Synthesis, Total Synthesis of natural Products, Development of new Synthetic methodologies.

Technical Officers

Mr. Gaurav Kumar Rastogi

Technical Officer

Education :M.Sc

ID. No.: 1242

Email: ratulsaikia@neist.res.in, rsaikia19@gmail.com

contact No : +91 0376-2370121extn 2344 Fax : +91 0376 2370011

Applied Organic Chemistry Group

R&D PROGRAMMES:

Speciality Chemicals:

  • Development of eco-friendly processes for the preparation of value added chemicals from wastes like rice straw, bamboo, grass etc
  • Oxidative transformation of lignin/degraded lignin products generated from microbially treated lignocellulosic materials’ for value addition

Small molecule libraries as anticancer and anti tuberculosis agent:

  • Synthesis of prenylated coumestane natural products like psoralidin, lespeflorin, glycyrol etc. and study of their activity against prostate cancer
  • Synthesis of small molecule libraries of Natural Products (NPs) and Natural Product like Molecules (NPLMs) by Function Oriented Synthesis (FOS), Diversity Oriented Synthesis (DOS), Diverted Total Synthesis (DTS), Target Oriented Synthesis (TOS) etc. for cancer therapy.
  • Synthesis of substituted quinoxaline and quinazoline derivatives for new anti tuberculosis agent

Development of methodology for the synthesis of promising organic molecules:

  • Development of methodologies involving C-C bond and C-X bond formation reactions
  • Development of methodologies for new scaffold library synthesis involving cascade/domino reactions
  • Application of green chemistry principals in synthesis of novel scaffolds

Development of synthetic methodologies for azaspirocyclic natural products like histirionicotoxin, erythratidinone, erysotramidine etc.

Acheivements

The AOCG has brought laurels to the institute by receiving several recognition and award at the National/International/State level which includes Fellow of the Indian National Science Academy (INSA), National Academy of Sciences (FNASc), CRSI Bronze Medal, Professor Harish Chandra Goswami Memorial Fellowship, Alexander von Humboldt fellowship (AvH), Germany, Dr Biraj Mohan Das Memorial Science Award, Elsevier Most Cited Paper Award etc

Research Facilities

The laboratory is well equipped with instruments like Polarimeter, Microwave reactor, Microwave Synthesis System, Flash chromatography, HPLC, Kugelrohr apparatus, Pressure reactor, Nitrogen gas generator, Low temperature bath (- 30 °C, -80 oC), Combiflash, Hydrogenation apparatus, Refrigerated centrifuge, Sonicator etc.