Bio-Data

Particulars of organization, functions and duties

Dr. Srinivas Ambala

Designation : Scientist

Education : Ph.D.

Contact Details: Natural Product Chemistry, CSTD, CSIR-NEIST, Jorhat-785001, Assam, India

Email id : srinivas@neist.res.in, ambalasrinivas2512@gmail.com

Research Interest

• Natural Product Chemistry, Medicinal Chemistry, Synthetic Organic Chemistry, Total Synthesis of Natural Products, and Development of new Synthetic methodologies.

• Mayor, S.; Vishwakarma R, A.; Singh, P, P, Swetha. S, Ambala, S, Munagala, G.; Yempalla, K, R et. al., Inhibitors to target HIV-1 NEF-CD80/CD86 interactions for therapeutic intervention.

  • WO2020035880A1,
  • EP3836933A1,
  • Patent filed: US 17/268440

• Ambala.S.; Singh, R.; Singh, M.; Cham, P, S.; Munagala.G.; Yempalla. K. R.; Vishwakarm. R. A.; Singh. P. P.; Metal-free, room temperature, acid-K2S2O8 mediated method for the nitration of olefins: an easy approach for the synthesis of nitroolefins.RSC Adv., 2019, 9, 30428-431.
• Ambala, S,;Thatikonda, T,; Sharma, S.;Munagala, G.; Yempalla, K, R.; Vishwakarma R, A.; and Singh,P, P.; Cross-dehydrogenative coupling of α-C(sp3 )–H of ethers/alkanes with C(sp2 )–H of heteroarenes under metal-free conditions.Org. Biomol. Chem. 2015, 13, 11341-11350.
•  Ambala S, Kimberleigh B, Kamal K, Thavendran G, Hendrik G, Naicker T, Per I. Arvidsson. N-Arylation of primary and tertiary sulfonimidamides (SIAs) with benzyne precursors under transition metal-free conditions. Tetrahedron Lett. 124, 2023, 154583
• Mayor, S.; Vishwakarma R, A.; Singh, P, P, Swetha. S, Ambala, S, Munagala, G.; Yempalla, K, R et. al., Inhibition of HIV-1 immune modulation by small molecules targeting viral Nef- host CD80 interface. https://doi.org/10.1101/2021.09.07.459239
• Gopathi. R,Ambala. S and; Bathini. N. Regioselective ring expansion of 3-ylideneoxindoles with tosyldiazomethane (TsDAM): A metal-free and greener approach for the synthesis of pyrazolo-[1,5-c]quinazolines. J. Org. Chem., 2020, 85, 8, 5370-5378.
• Gopathi. R, Ambala S, Jagadeesh. B. N.; Bathini N. Regioselective ring expansion followed by H-shiftof 3-ylidene oxindoles: a convenient synthesis of Nsubstituted/un-substituted pyrrolo[2,3-c]quinolines and marinoquinolines. RSC Adv., 2019,9, 35068–35072.
• Rajbongshi. K. K.; Ambala, S.;Govender T.; Kruger H. G.; Arvidsson. P. I; Tricia N. T.; Metal-free, Radical-Induced Acylation of Sulfoximines from Aldehydes.Synthesis 2020, 52, A-H.DOI: 10.1055/s-0039-1691589.
• Thatikonda, Singh, U.; Ambala, S.;Vishwakarma R, A.; and Singh,P, P.;Metal free C–H functionalization of diazines and related heteroarenes with organoboron species and its application in the synthesis of a CDK inhibitor, meriolin 1. Org. Biomol. Chem. 2016, 14, 4312-4320.
• Singh,P. P.; Gudup, S.; Ambala, S.; Singh,U.;Dadwal. S.; Sawant, S. D.; Vishwakarma, R, A; Iron oxide mediated direct C–H arylation/alkylation at a-position of cyclic aliphatic ethers.Chem. Comm., 2011, 47, 5852-5854.
• Singh,P. P.; Gudup, S.; Aruri, H.; Singh,U.;Ambala, S.;Sawant, S. D.; Vishwakarma, R, A.; New method for C–H arylation/alkylation at α-position of cyclic aliphatic ethers by iron-oxide mediated reaction. Org. Biomol. Chem., 2012, 10, 1587-1597.
• Ranajit. D.; Michael. C.; Colette. L.; Jacques. P.; Ambala, S.; Christelle. G.; Gouri. P. R.; Pascale. D; Tripodal scaffolds with three appended imidazole thiones for Cu(I) chelation and protection from Cu-mediated oxidative stress. J. Inorg. Biochem.222 (2021) 111518.

• Scientist at Sai Lifesciences-Hyderabad (02/2022-01/2023)
• National Postdoctoral Fellowship at IICT-Hyderabad (2019-2021)
• Post-Doctoral Fellowship at the University of Kwazulu Natal, South Africa (2017-2018).
• Research Associate, Shiv Nadar University-Noida (2016-2017)
• Senior Research Fellowship (SRF), Council of Scientific and Industrial Research (CSIR), India (2011-2014).
• Junior Research Fellowship (JRF), Council of Scientific and Industrial Research (CSIR), India (2009-2011).